Study of Mice and Health
Student Artists: Vincent Perez
Course: Data Visualization with Lucy HG Solomon
Researcher: Dr. Julie Jameson, CSUSM Biology
I did my project on Dr. Julie Jameson’s study, Immunomodulation at epithelial sites by obesity and metabolic disease. It is about the impact obesity has on T-cells. These T-cells are responsible for protecting the epithelial barrier as well as mediating repair. When obese, the count of the T-cells goes down (as well as a number of other harmful side effects). I created two models – one of a lean mouse with healthy T-cells and one of an obese mouse with unhealthy T-cells.
Although it looks like a sixth grade project, I decided to make it crafty in hopes that it would be easier to understand.
Representation of Project Data
This project’s data consists of an eighteen page research paper that goes over the impact of obesity on T cells. It also contains diagrams to explain some of the ideas presented.
Below are my notes collected to understand scholarly article.
The process for me – beside crafting the visual – includes understanding the function of T-cells and the impact obesity has on T-cells and T-cell function. It also includes obtaining knowledge of what happens to the T-cells and epithelial barrier once the mice become Obese.
When adipose tissue rises, or you become obese, T-cell count decreases and the function becomes negatively modulated. When obese, T-cells become less effective and sometimes ineffective in epithelial repair, thus causing deterioration of the epithelial barrier. Deterioration of the epithelial barrier causes increased inflammation levels as well as an increased risk of infections. The article goes into detail about the impact of obesity and may be hard to understand for some people, so I aimed to recreate a diagram that would be a little simpler to read and give a general overview of the study.